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This is particularly true in those patients who have T4 to T3 conversion disorders and often do not fare well on synthetic T4 (Synthroid) alone

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Hum Genet 138:13591377 Schiff MH, Jaffe JS, Freundlich B (2014) Head-to-head, randomised, crossover study of oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at doses 15 mg may be overcome with subcutaneous administration

As for blood cells, only a handful of studies, with modest sample sizes and almost exclusively featuring platelets, have examined age-related mitochondrial decline, and the results have been inconclusive 18,19,20,21,22,23

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