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These enzymes contribute to cellular reactions, such as antioxidant defense, drug detoxification, and cell signaling [33]

doi: 10.1038/s41398-019-0490-x 327 SnijdersG

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All these findings proved that Dula had a preventive effect against colitis-induced AA that may be posted by its ability to reduce oxidative stress damage

To develop cardiac insulin resistance, major factors such as hyperglycemia, hyperlipidemia, oxidative stress, inappropriate activation of sympathetic nervous system and the renin-angiotensin II-aldosterone system (RAAS), and dysregulated secretion of adipokines/cytokines are all significant contributors [139]