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The well-studied large phi (GSTF) and tau (GSTU) classes are specific to plants whereas the small zeta (GSTZ) and theta (GSTT) classes exist also in animal tissues (Dixon et al., 1998, 2002)

To obtain the purified recombinant GHK peptide, the crude protein was incubated with a HisTrip HP His tag protein purification column (GE Inc., Marlborough, MA, USA) for 2 h in a 4 C room

Response: We thank commenters for their support of this proposal

In turn, T cells produce inflammatory cytokines, such as IL-17 and IL-23, which exacerbate skin inflammation (206, 209)

If needed, TB-500 can be continued to be taken at 1mg/daily until achieving full recovery among test subjects