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By improving HRV, L-carnitine helps shift the autonomic nervous system out of chronic sympathetic overdrive (the "fight or flight" state) and enhances parasympathetic vagal tone (the "rest and digest" state), promoting a calmer, more regulated nervous system response to physical stressors

The work underscores celastrol's promise as a pharmacological option for combating obesity and its metabolic repercussions, advocating for further investigation into its mechanisms and therapeutic applications [50]

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Ex-4 also modulates the influx of calcium through L-type voltage-dependent calcium channels (L-VDCCs) and N -methyl-d-aspartate receptors, and it maintains the expression of phosphorylated calcium/calmodulin-dependent protein kinase type II [73]

Constipation also happens, sometimes alternating with diarrhea