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Your healthcare provider may tell you to take XIGDUO XR along with other diabetes medicines

Suspected adverse reactions should be reported to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk

[2] Always consult with a healthcare provider before making changes to your supplement regimen to ensure they fit your health needs

Metabolism & Elimination The metabolic fate of GLP3 has been partially characterized in clinical pharmacology studies[17]: Mean elimination half-life of approximately 6 days in healthy adults and patients with type 2 diabetes Hepatic metabolism represents the primary clearance pathway Does not interact with cytochrome P450 enzyme systems, minimizing potential drug-drug interactions Likely undergoes peptidase-mediated degradation and proteolytic cleavage The three non-coded amino acid modifications confer resistance to dipeptidyl peptidase-4, contributing to extended half-life The prolonged half-life enables once-weekly dosing while maintaining therapeutic drug concentrations throughout the dosing interval, with minimal peak-to-trough fluctuations that could contribute to side effects or reduced efficacy

Proc Natl Acad Sci USA