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In the SURMOUNT clinical trial program for obesity, participants achieved average weight loss of 15-21% of body weight depending on dose, significantly exceeding results with diet and exercise alone or other available pharmacotherapies
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Conducted in artificial cell lines, the findings did not address the key question as to whether the truncated form of GLP-1 located in the gut activated the pancreas to release insulin in the way incretin was presumed to work
GLP-1s still account for a relatively small share of the total number of Medicaid prescriptions, accounting for about 1% of all Medicaid prescriptions in 2024 (up from about 0% in 2019)
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