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absent before infection), persisting for at least 12 weeks since infection, present at the time of assessment, and impairing everyday functioning

As for CASP3, studies have shown a correlation between abnormal expression and BRCA patient prognosis, and an abnormal CASP3-mediated apoptosis pathway is a potential mechanism of chemoresistance in BRCA 40,41

FOXOs: signalling integrators for homeostasis maintenance