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Gradual dose escalation over 4-8 weeks allows adaptation while building toward effective maintenance doses

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Madej, The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome

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Glucagon has its own effects on the digestive system, including influences on bile secretion, hepatic glucose output, and gut motility patterns that differ from GLP-1 effects