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10.1016/j.clnesp.2024.01.015 173 TalenezhadN.MohammadiM.Ramezani-JolfaieN.Mozaffari-KhosraviH.Salehi-AbargoueiA

Additionally, obesity and IR both contribute to -cell dysfunction and apoptosis, mechanistically explained by glucotoxicity and increased immunogenicity (the accelerator hypothesis) or by -cell exhaustion due to increased metabolic demand (the overload hypothesis) [23]

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Critical storage parameters One detail that catches researchers off guard: degradation can happen without any visible change to the solution