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As a rule, drugs become much more inexpensive once other companies can produce generic versions of them, which is why pharmaceuticals typically do everything they can to delay the expiration of their relevant patents

There are many other potential causes of histamine intolerance including: Environmental causes such as pollen and dust mites Excessive alcohol intake A diet too high in fermented foods, too much protein, and consuming aged foods Hormonal excess, particularly estrogen Adrenal dysfunction Lack of sleep Stress & anxiety Nutrient deficiencies Gut infections & more Symptoms of Histamine Intolerance Some of the most common symptoms of histamine intolerance are as follows: Headaches Diarrhea Eczema or hives Irregular heartbeat Low blood pressure Wheezing Runny nose Heartburn Premenstrual syndrome Seasonal allergies Food allergies Asthma Motion sickness Nausea Vomiting Irritability Loose stool Chest tightness Histamine intolerance commonly goes undiagnosed because many of the symptoms mimic an allergic reaction

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Specifically, we demonstrated that GLP-1MK-801, but not the parent GLP-1 analogue, suppressed NMDA-induced inward currents (Extended Data Fig