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Keywords: Calorie restriction mimetics, Calorie restriction facilitators, Consensus, GLP-1 RA, Incretin-based therapies, Type 2 diabetes mellitus Executive Summary The current report is an overview of current knowledge on glucagon-like peptide-1 receptor agonists (GLP-1 RAs) based on pragmatic review of the available clinical evidence on use of GLP-1 RAs in the management of type 2 diabetes mellitus (T2DM)

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Activating both receptors can improve insulin secretion, enhance fat metabolism and amplify appetite suppression

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