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While all cell types were affected, senescence was most pronounced in the acinar cells and fibroblasts

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Candidate genes within these intervals include transcription factor families (MADS-box, bHLH, NAC, and MYB), energy-metabolism enzymes such as malate dehydrogenase, and cytoskeletal components, illustrating how regulatory and metabolic pathways converge during stress adaptation

10.1016/S2213-2600(15)00543-3 54 HorioT.KamideK.TakiuchiS.YoshiiM.MiwaY.MatayoshiT.et al (2010)

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice