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371 have reported that ADA3 is over expressed in breast cancer patients and as a transcriptional co-activator, human ADA3 (hADA3) interacts with ER, thereby transactivating its downstream targets leading to breast cancer progression

Immunity 41 , 3648 (2014)

Additionally, patients should be counselled that TCAs have a delayed onset of therapeutic effect, often requiring several weeks before clinical improvement is evident

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Understanding proper injection technique, site rotation, and how to avoid common mistakes helps minimise injection site reactions and ensures optimal therapeutic outcomes