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Vaccination with a mutated form of Na-APR-1 significantly reduced parasite burden in experimentally-infected canines ( fur has proven effective in attenuating NTHi disease severity/duration in animal models of OM and lung infection (Morton et al., 2004

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identified that GHK-Cu upregulates approximately 4,000 genes and downregulates an additional 4,000, with clustered effects in pathways governing extracellular matrix synthesis, anti-inflammatory signaling, and DNA repair