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This development reinforces the central message that success in oral delivery depends on molecular properties rather than delivery platforms

These medicines are generally well tolerated, although gastrointestinal side effects are common during treatment initiation or dose escalation

Indeed, clinical trials with FGF-21 analog monotherapy (e.g., pegbelfermin, efruxifermin, and BOS-580) have generated favorable results in NAFLD, as elsewhere summarized [52]

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Interestingly, administration of an antibiotic along with olanzapine minimized the amount of the weight gain in rodents, a finding that may be in line with the antibiotic minocycline reducing psychotic symptoms in patients with schizophrenia