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Upon activation, calcineurin dephosphorylates and stimulates TFEB, which in turn translocates into the nucleus where it binds to the coordinated lysosomal expression and regulation (CLEAR) sequence to upregulate expression of several genes involved in the autophagic pathway (Tong and Song, 2015
Functional mechanotransduction is a known requirement for aminoglycoside entry into hair cells and its resulting ototoxicity (Alharazneh et al., 2013)
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Dopamine Pharmacodynamics: New Insights
For instance, these measures include payment schemes, commercialization awards, patent purchases, and publicprivate partnerships in which public funding helps R&D at different development stages in pharmaceutical and biotech companies [61]
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