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Melatonin and serotonin 5-HT2C receptors were demonstrated to be coexpressed in various areas of the CNS, possibly including POMC/CART neurons, explaining the frequently discussed antiobesity effect of melatonin (121)

While both peptides have been shown to cause sunless tanning, MT1 is considerably more selective towards the MC1R

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However, because BPC-157 has not been approved by the FDA for any medical use, it cannot be legally marketed as a drug or sold as a dietary supplement