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(10 g or 10 ng/kg/day), topical (1.0 g in cream), or per-oral (0.16 g/mL in drinking water) over 90 days and described directional improvements across biomechanical, functional, macroscopic, and histological endpoints, though specific effect sizes and p-values are not reported in the abstract

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TB-500, on the other hand, enters the bloodstream and spreads everywhere injection site doesn't matter for that component

* Perianal swelling or pain (especially thrombosed external hemorrhoids)

The Effects of Proton Pump Inhibitors in Acid Hypersecretion-Induced Vitamin B12 Deficiency: A Systematic Review (2022)