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GLP-1 modulates actin polymerization, improving insulin sensitivity and glucose-stimulated insulin secretion Chronic hyperglycemia, or glucotoxicity, causes pancreatic cell dysfunction, diminished glucose-stimulated insulin secretion, and the production of long actin stress fibers 6,7

Sleep and Stress Management: Poor sleep and chronic stress may negatively affect insulin regulation and appetite hormones

doi: 10.1210/endocr/bqab079 24 BorzoueiSMoghimiHZamaniABehzadM

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The accumulation of various substances (e.g., carotene, glycosylated proteins) in patients with diabetes may be responsible for the changes in complexion