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The most common adverse events were dose-related gastrointestinal symptoms, primarily nausea, which were previously seen with GLP-1 receptor agonists
Plaintiffs argue that companies like Novo Nordisk and Eli Lilly ignored clinical trial data, post-marketing surveillance, and adverse event reports that pointed to dangers such as stomach paralysis, intestinal obstruction, and permanent vision damage
Although the tissues involved in tocochromanol catabolism are not well identified, CYP4F2 is expressed in liver and kidney (18), as well as intestine (19)