In Vivo Assessment of Drug Interactions Effects of Sitagliptin on Other Drugs In clinical studies, sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, digoxin, warfarin, or an oral contraceptive (ethinyl estradiol and norethindrone) (Table 4), providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, P-gp, and organic cationic transporter (OCT)
J Biol Chem (2001) 276(32):2983945
Well look at why this distinction is important in a minute when we look at the benefits of them both
The results of these analyses were consistent with the primary approach (Table S10)
Vitamin D deficiency is common and can be harder to avoid during reduced intake