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Your prescriber may recommend a dose increase if you've maintained your current dose for 8-12 weeks without new progress

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At present, the only GLP-1 products on the shortage list are dulaglutide, sold by Eli Lilly under the Trulicity brand, and liraglutide which Novo Nordisk sells as Victoza

Notably, neuromodulatory effects elicited by the microbiome are largely dependent on vagal signaling (Bravo et al., 2011

Pemvidutide, developed by Altimmune, is a GLP-1/glucagon dual agonist that has completed Phase 2 trials for obesity (MOMENTUM, 15.6% weight loss at 48 weeks) and MASH (IMPACT, up to 59.1% MASH resolution)