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Sears SM, Hewett SJ (2021) Influence of glutamate and GABA transport on brain excitatory/inhibitory balance

In some embodiments, the otic formulation or composition comprises about 19% by weight of the silicon dioxide

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This work is suspected of not respecting ethical and scientific standards and is, for some, the subject of ongoing legal proceedings. After years of criticism, including a 2023 letter raising serious concerns about methodological flaws in the study and an editorial conflict of interest (one of the co-authors was also editor-in-chief of the journal), the journal finally issued a lengthy retraction notice

Others argue the opposite, that consistent low-dose activation maintains the beneficial signaling