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Effects of GLP-1RAs on neurogenesis and neuroplasticity Neurogenesis, consisting in the formation of new neurons from neural stem and progenitor cells located in various brain regions, such as the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone of lateral ventricles, has the potential to reduce neuronal damage and restore neurological function after a stroke [93]

Even reduced doses of GLP-1 medications may not provide adequate appetite suppression, and the transition period often triggers compensatory eating behaviors

No FDA status Not FDA-approved Compound AOD-9604 Mechanism Modified GH fragment

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( f-g ) H4K12ac or H3K23ac chromatin immunoprecipitation in U2OS-mCherry-LacI-Fok1 cells treated with the IDH1 inhibitor ( f ) or transduced with shRNA targeting TMLHE (shTMLHE) ( g ) alone or supplemented with KG or l-carnitine (l-carn) supplementation (n = 3 technical replicates representative from 2 independent experiments)