Dietary Fiber: Essential for a Healthy Diet
The Clinical Data: Everything Published So Far Phase 1 First-in-Human (Oral Formulation) Published: The Lancet, June 2025 Participants: 144 adults with overweight or obesity (BMI 25.039.9), no diabetes Duration: Up to 12 weeks Dosing: Once-daily oral amycretin, up to 2 50 mg Results: - 50 mg dose: 10.4% mean body weight change - 2 50 mg dose: 13.1% mean body weight change - Placebo: 1.2% 13% weight loss in 12 weeks
ResultsGut hormones and food intake During and after meal, ingested nutrients alter the release of gut peptides that may potentially modulate the food intake and contribute to a three-steps process: meal initiation, within-meal satiety and across-meal satiety influences.4 Meal initiationGhrelin Originally isolated as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R) and for its capacity to stimulate growth hormone (GH) secretion, ghrelin is also the only orexigenic signal from the gastrointestinal tract and a long-term regulator of energy homeostasis.5 This 28 amino acid peptide is modified post-translationally with an eight-carbon fatty acid by the enzyme ghrelin-O-acyl-transferase (GOAT)
If you begin treatment with lower muscle mass, you face greater vulnerability to functional losses
regulation of the airway microbiota (e.g., probiotic supplementation) can improve host metabolic and immune imbalances (128, 129)
