So post-GLP-1, your knees may no longer be overloaded by mass, but theyre still: Tracking according to old alignment (valgus/varus habits, rotational patterns) Responding to trunk and pelvis strategies that were built around a forward-shifted center of gravity Low back & spinal curves Multiple studies now connect abdominal obesity with: Increased lumbar lordosis and altered spinal alignment Greater gravitational torque on the lumbar spine Higher likelihood of low-back pain independent of age and activity level
Medical supervision matters most for people with diabetes, cancer history, abnormal growth hormone or IGF-1 levels, thyroid concerns, heart disease, kidney issues, or unexplained swelling
Besides, -catenin is reported to interact with GATA TF to regulate its activity (Iyer et al, 2018)
and i.v
They support their claim that many chronic diseases would benefit from effective weight management with a single citation which is a speculative editorial (Treating chronic diseases without tackling excess adiposity promotes multimorbidity) whose authors take a ton of money from the weight loss industry, including Novo Nordisk
