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The storage lesion is exacerbated in some categories of donors as a function of biology (sex, age) 21 , genetic traits 22,23,24,25 , and lifestyle-associated exposures 26 (comprehensively reviewed in 15,21,27,28

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The abdomen is generally the least painful site for most people

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As biological matrix can metabolize spiked pure compound we added each NAD form individually at different stages of the extraction (Supplementary Table 1) and followed recovery in enzymatic assays