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Ghrelin (the hunger hormone) may initially rise during a calorie deficit but often becomes more manageable with consistent dietary patterns over time

PYY is predominantly colocalized with GLP-1 and would be expected to be secreted in parallel with GLP-1, 40, 41 but previous reports have shown that some conditions may favor release of one hormone over the other 42 and that there may be cells that preferentially release PYY or GLP-1 rather than both hormones in parallel

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the medication will work effectively either way as long as you maintain a consistent weekly schedule