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Ethics statement The studies involving humans were approved by Research Ethics Committee, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

Gastroenterology 150:1393407.e5 Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J et al (2016) Gastroduodenal disorders

For each criterion, we performed univariate analyses followed by a multivariate analysis using a linear stepwise regression model, in which significant variables at the P = 0.20-threshold in the univariate analyses, were included

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Most people require multiple sessions to achieve visible results, and maintenance sessions may be needed to sustain the whitening effect