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The JQ1 moiety of ZZ1 interacts with its canonical binding site on BRD4 BD1 and the appended degron protrudes out of the BRD4 BD1 pocket, creating a neomorphic surface for YPEL5 engagement (Fig

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PT-141 is a synthetic peptide that binds to melanocortin-4 receptors (MC4R) in the hypothalamus the brain region that regulates sexual behavior, appetite, and autonomic function