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Here are five potential side effects that some patients may experience, most of which are mild and temporary: Mild Injection Site Discomfort Some people may feel slight redness, swelling, or soreness at the injection site, which usually resolves quickly

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Neurogenic inflammation in acute migraine attacks is characterized by a TVS activation-induced release of neuropeptides, such as CGRP and substance P, from trigeminal nerve fibers at the dura, which causes increased vascular permeability, plasma protein extravasation, leukocyte infiltration, vasodilation, mast cell degranulation, activation of meningeal nociceptors, and the subsequent release of inflammatory mediators (5)