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A reduced GSH status can further compromise the defense against oxidative stress and increase the oxidative modification of proteins or enzymes, causing major changes in the secondary structure that result in the impaired metabolic stability and function of modified proteins or enzymes [78,97]

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This metabolically active WAT produces interleukins, adipokines, antimicrobial peptide (AMP) cathelicidin [36, 37] and possibly collagen type VI (COL6) contributing to disease mechanisms [38,39,40,41,42,43,44,45,46,47]

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10.1016/j.physbeh.2017.03.019 21 FreetC