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2a, b) highlights the importance of the bioavailability of cysteine to enable cells to adapt to metabolically challenging conditions, as well as mediating cancer cell survival, tumour growth, metastases formation, resistance to therapy and disease recurrence

It is well known that N-acetyl-p-benzoquinoneimine, a toxic metabolite of acetaminophen is detoxified by hepatic GSH

CYS, cysteine

Within the brain ethanol-derived acetate has been found to directly bind to neuronal chromatin where it is converted to acetyl-CoA via chromatin-bound acetyl-CoA synthetase 2 (ACSS2)

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