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4.4 Ferroptosis and multiple sclerosis Multiple sclerosis (MS), a chronic inflammatory condition of the central nervous system, is characterized by neuroinflammation, demyelination, oligodendrocyte loss, and neurodegeneration (146, 147)

In rice, the expression of biosynthetic genes: tryptamine 5 hydroxylase ( T5H ), tryptophan decarboxylase are over expressed on heavy metal stress to secure MT biosynthesis [10]