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Slower Gastric Emptying: Semaglutide slows down the rate at which food empties from the stomach, prolonging feelings of fullness and reducing the urge to eat between meals

It also slows gastric emptying, making us feel fuller for longer

10.1016/j.jconrel.2017.03.019 212 ZhangJ.SunY.QuQ.LiB.ZhangL.GuR.et al (2021)

Tirzepatide is injected into the fatty layer beneath the skin (subcutaneous injection), which is particularly rich in small capillaries vulnerable to needle trauma

Over a 10-year period, patients who underwent weight-loss surgery (also called bariatric or metabolic surgery) lost more weight, maintained better blood sugar control, and needed fewer prescriptions for diabetes and heart conditions