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This sex difference disappears after menopause with the incidence of mood disorders becoming similar in men and women, supporting a key role of estrogen in mood disorders [77]

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Blommel PG, Martin PA, Wrobel RL, Steffen E, Fox BG (2006) High efficiency single step production of expression plasmids from cDNA clones using the Flexi Vector cloning system

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Activation of those genes, in turn, has been shown to be related to extended lifespans in a wide variety of organisms