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If blood pressure rises above 140/90 or joint pain limits range of motion, discontinue IGF-1 LR3 for 57 days to allow fluid clearance before resuming at lower dose

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La sustitucin o dieta de restriccin en las enfermedades hereditarias fetales metablicas como acidemia metilmalnica (MMA) (tratados con vitamina B12), deficiencias de carboxilasa (tratado con biotina), 3-fosfoglicerato-deshi- drogenasa (3-PGDH) (tratados con L-serina)