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Cons: Lower Weight Loss Potential: The lower and slower absorption of semaglutide might result in less substantial weight loss, though individual responses differ significantly

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Yamanaka H et al

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From the comparative analysis of the results of comparative example 1 and examples 19, 20, 21 and 22, the synthesis of semaglutide was performed after introducing an ionic liquid Linker on the PS resin solid phase support, and the crude peptide purity and the refined peptide yield were much better than those of the standard Fmoc solid phase polypeptide synthesis method