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[64], treatment with acetyl-l-carnitine (500 mg twice daily intramuscularly for 10 days followed by 2000 mg daily administered orally for 355 days) resulted in improvement in neurophysiological parameters and pain reduction over a 1-year period [64]

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Of note, some studies have indicated that A itself could play a role in the pathological mechanisms associated with AD

Namely, eNOS, iNOS and COX2 activity are thought to be specifically up-regulated in myocardial infarction [38]

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