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PTEN phosphatase inhibits the activity of PI3K and thus impedes signaling through the insulin/IGF-1 pathway (Fig

Cell culture and transient transfection The chicken Leghorn male hepatoma (LMH) cells were obtained from ATCC (Manassas, VA, USA)

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The regeneration of GSH after an APAP dose is also affected by the concentration of glutamate in the liver and it is known that supplementation of rats with glutamine prior to and APAP over dose acts to preserve GSH levels

Marsden et al., 1992)