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These compounds help catalyze the breakdown of fat during metabolism, with the liver serving as the central hub for this activity

The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene

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Exogenous supplementation with neuregulin 4 can alleviate liver damage in septic mice by increasing the expression of GSH, SLC7A11, and GPX4 and effectively inhibiting hepatocyte ferroptosis (Feng et al., 2025)

however, current human evidence remains limited, heterogeneous, and largely associative