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Beyond being a building block for proteins, cysteine has roles that include supporting the generation of antioxidants (for example, glutathione and persulfide species) 10 , metabolites (for example, H 2 S, CoA and hypotaurine) 11,12 and ironsulfur clusters for mitochondria 13

Topline data from the Phase 3, open-label EMBER-3 clinical trial among patients with estrogen receptor 1 (ESR1) gene mutations who received prior endocrine therapy revealed a median progression-free survival (PFS) of 5.5 months with imlunestrant compared to 3.8 months with placebo (hazard ratio [HR], 0.62