A practical periconception management approach is as follows: (i) Target achievement: Continue treatment alongside lifestyle intervention until pre-specified weight and metabolic targets are met (e.g., 5%10% weight loss with improvement in IR markers)
The bloating sensation in my abdomen is no longer there, and my digestion is stronger even though my diet remains the same as before
However, few prospective studies have conducted prespecified, systematic causal pathway analyses linking these metabolic improvements to reproductive endpoints such as ovulation, clinical pregnancy, or live birth rates
It produces worse side effects, more discontinuations, and often slower progress because severe GI symptoms prevent adequate nutrition and hydration
My hormone doc suggested giving semaglutide a try (Ozempic, Wegovy)