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In alzheimers disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, Placebo-Controlled, double-blind clinical trial

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In line with our short-term metabolic analyses, previous studies in New Zealand obese and diet-induced obese male mice suggested that GLP1/E acts primarily at central levels to reverse metabolic alterations by decreasing food intake and body weight, while the potential beneficial effects on pancreatic beta-cells were possibly secondary and indirectly-mediated 33,48

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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Nauck M.A., Meier J.J