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Subsequently, absorptive progenitors differentiate into enterocyte cells, while secretory progenitors differentiate into Paneth, goblet, tuft cells, and EEC progenitors
368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption
Clinical trial data from the SURMOUNT and SURPASS programs showed tirzepatide producing average weight loss of 20 to 25 percent of body weight at the highest doses, compared to 15 to 17 percent for semaglutide at comparable doses
Final Thoughts GLP-1 agonists represent an interesting and evolving area of research in autoimmune care, particularly due to their effects on metabolic health