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Rapid escalation increases side effect severity, particularly nausea and gastrointestinal distress

In the UK, hydroxocobalamin is the standard injectable form of B12 used in NHS practice

Compounds such as curcumin, which possess both antioxidant and anti-inflammatory properties, have been investigated for their potential to ameliorate DN by regulating the MAPK signaling pathway (Li et al., 2022)

Table 1 The negative effects of TMAO on atherosclerosis demonstrated via clinical and non-clinical experiments