It is safe and well-tolerated by most people, but medical advice is recommended for long-term use
Weight Loss (%) Weekly/Oral Notable Effects Semaglutide (Wegovy) 14.9% Weekly injection Strong appetite suppression Liraglutide (Saxenda) 810% Daily injection More nausea reported Tirzepatide (Zepbound) 1520% (trials) Weekly injection Dual hormone action (GIP + GLP-1) Orlistat 57% Oral Fat malabsorption side effects Semaglutide consistently outperforms most prescription weight loss medications in both efficacy and tolerability
Al-Naamani, Frank Tacke, Emmanouil Tsochatzis, Javier Crespo, Mohamed El-Kassas, Fernando Bril, Marco Arrese, Cyrielle Caussy, C
Orforglipron discontinuation rates due to side effects ranged from 5.3-10.3%, while tirzepatide rates were 4.3-7.1%
PepsiCo has posted five consecutive quarters of declining savoury snacks volume