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Studies in isolated islets and in vivo models suggest that GIP and GLP-1 receptor activation can work through distinct but complementary pathways to enhance beta cell function

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Butyrate is more readily transported by SLC5A8,which is relatively a high-affinity transporter with affinities for the butyrate in the sub-millimolar range (73)

Understanding these mechanisms explains why certain peptides show such compelling neuropathy research and why a multi-peptide approach often makes more sense than targeting a single pathway

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