why not use dpp4 and glp 1 together Insights into the Roles of GLP-1, DPP-4, SGLT2 at the Crossroads of Cardiovascular, Renal, and Metabolic Pathophysiology Therapeutic Effects of GLP-1 Receptor

According to Ferraz-Bannitz, previous in vitro studies had already shown that serotonin is able to stimulate the secretion of insulin in pancreatic beta cells and GLP-1 in intestinal neuroendocrine cells

This means they can send direct signals to cells, helping to trigger specific responses like reducing inflammation, speeding up tissue repair, or supporting immune function

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Consequently, our data illuminate a novel role of IGF-1 in regulating stress-induced hepatocyte premature senescence in liver fibrosis: prolonged IGF-1 relieves oxidative stress-initiated hepatocyte premature senescence via inhibition of nuclear p53progerin interaction to ameliorate hepatic steatosis and fibrogenesis