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doi: 10.1016/S0021-9258(20)82128-0 48 DeBerardinisRJMancusoADaikhinENissimIYudkoffMWehrliSet al

Each hair follicle is a dynamic mini-organ, cycling through three distinct phases: the anagen phase (active growth, lasting two to six years), the catagen phase (a brief transitional period), and the telogen phase (rest, during which the hair sheds)

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Under conditions of metabolic stress, it migrates to the cell nucleus, where it activates a suite of genes governed by AMPK (AMP-activated protein kinase), the master cellular energy sensor